The research team of the School of Pharmacy of Sun Yat-sen University published a paper in the global core toxicology journal "ARCHIVES OF TOXICOLOGY" ("ARCHIVES OF TOXICOLOGY"), pointing out that at the same nicotine dose, e-cigarette aerosol is less harmful to the respiratory system than cigarette smoke.
The impact of e-cigarettes is a hot topic in the field of health and wellness. This time after time research, the similarities and differences of the influence of Zhongshan protein expression in Zhongshan research, fills up the scientific research gap in related fields.
The researchers selected a certain brand of e-cigarette and a certain commercially available cigarette as samples, and randomly divided 32 mice into 4 groups, which were exposed to clean air, low-dose e-cigarette aerosol, high-dose e-cigarette aerosol, and cigarette smoke. 10 weeks, and analyze its various indicators.
The pathological results of the lung tissue showed that the lung coefficient of the mice exposed to cigarettes was significantly increased, and the shape of the trachea was changed, suggesting that the respiratory system may have lesions. In contrast, there was no significant change in lung coefficient and no change in tracheal morphology in mice exposed to e-cigarettes.
The lung function test found that cigarette exposure caused significant abnormalities in multiple lung function indicators in mice, but only one indicator decreased in the e-cigarette group. At the same time, pathological results showed that both cigarettes and e-cigarettes may cause abnormalities in the lungs of mice, but the damage caused by cigarettes was more obvious.
Serum inflammatory factor detection and transmission electron microscopy found that both cigarettes and electronic cigarettes can cause airway inflammation, but cigarettes are more harmful. E-cigarettes cause less pathological damage to mouse trachea even at twice the nicotine content of cigarettes.
Finally, the researchers also performed a proteomic analysis of mouse lung tissue. The results showed that the differential protein changes caused by cigarettes were more concentrated in inflammation-related pathways, while the abnormal expression caused by e-cigarettes was less and had less impact on inflammatory signaling pathways.
The researchers said the findings clearly show that exposure to larger inhaled doses of cigarettes and e-cigarettes is harmful to the respiratory system. However, under the same nicotine dose, e-cigarette aerosol is less harmful to the respiratory system than cigarette smoke.
